Kosuke Aritake Selected Research

Prostaglandin D2

11/2021	L-PGDS Attenuates Acute Lung Injury by Prostaglandin D2 in Both Dependent and Independent Ways.
1/2019	Epithelial cell-derived prostaglandin D2 inhibits chronic allergic lung inflammation in mice.
1/2019	L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance.
11/2018	A gain-of-function study of amelioration of pentylenetetrazole-induced seizures by endogenous prostaglandin D2.
1/2018	Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells.
12/2017	Prostaglandin D2 metabolite in urine is an index of food allergy.
1/2017	Mast cell-derived prostaglandin D2 attenuates anaphylactic reactions in mice.
1/2017	Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2.
1/2016	Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis.
7/2015	PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.

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Kosuke Aritake Research Topics

Disease

15	Inflammation (Inflammations) 01/2021 - 04/2006
5	Pneumonia (Pneumonitis) 01/2019 - 01/2002
5	Neoplasms (Cancer) 01/2018 - 02/2007
4	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 11/2021 - 05/2009
4	Asthma (Bronchial Asthma) 01/2021 - 01/2002
4	Insulin Resistance 01/2019 - 03/2010
4	Body Weight (Weight, Body) 01/2019 - 06/2006
3	Food Hypersensitivity (Food Allergy) 01/2021 - 07/2015
3	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2021 - 11/2006
3	Narcolepsy 01/2021 - 01/2018
3	Obesity 01/2019 - 04/2011
3	Seizures (Absence Seizure) 11/2018 - 03/2014
3	Colitis 12/2017 - 03/2011
3	Hypersensitivity (Allergy) 07/2011 - 01/2002
2	Acute Lung Injury 11/2021 - 03/2013
2	Cataplexy 01/2021 - 01/2018
2	Hyperplasia 12/2017 - 07/2015
2	Dermatitis 12/2017 - 01/2014
2	Colonic Neoplasms (Colon Cancer) 06/2014 - 02/2007
2	Fibrosis (Cirrhosis) 11/2012 - 04/2011
2	Pain (Aches) 10/2012 - 06/2011
2	Contact Dermatitis (Eczema, Contact) 07/2011 - 08/2006
2	Type 2 Diabetes Mellitus (MODY) 03/2010 - 06/2007
2	Atherosclerosis 03/2010 - 06/2007
2	Globoid Cell Leukodystrophy (Krabbe Disease) 05/2006 - 04/2006
1	Pulmonary Edema 11/2021
1	Cardiomegaly (Heart Hypertrophy) 11/2021
1	Dementia (Dementias) 01/2021
1	Idiopathic Hypersomnia 01/2021
1	Hyperalgesia 01/2020
1	Nervous System Diseases (Neurological Disorders) 01/2018
1	Melanoma (Melanoma, Malignant) 01/2018
1	Sleep Paralysis 01/2018
1	Squamous Cell Carcinoma of Head and Neck 01/2018
1	Hallucinations (Hallucination) 01/2018
1	Disorders of Excessive Somnolence (Hypersomnia) 01/2018
1	Allergic Rhinitis 12/2017
1	Atopic Dermatitis (Atopic Eczema) 12/2017
1	Anaphylaxis (Anaphylactic Shock) 01/2017
1	Ureteral Obstruction 01/2017
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2016
1	Colitis-Associated Neoplasms 06/2014

Drug/Important Bio-Agent (IBA)

24	Prostaglandin D2IBA 11/2021 - 04/2006
17	prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA 02/2021 - 01/2002
15	LipocalinsIBA 11/2021 - 01/2002
15	ProstaglandinsIBA 01/2019 - 04/2006
13	Prostaglandins DIBA 01/2019 - 01/2002
5	EnzymesIBA 11/2018 - 02/2007
4	Proteins (Proteins, Gene)FDA Link 11/2021 - 04/2007
4	CytokinesIBA 11/2021 - 01/2002
4	prostaglandin D2 receptorIBA 01/2018 - 08/2006
4	LipidsIBA 01/2017 - 01/2002
3	AntigensIBA 07/2015 - 06/2006
3	Dinoprostone (PGE2)FDA Link 06/2014 - 06/2006
3	Glucose (Dextrose)FDA LinkGeneric 04/2011 - 06/2007
2	11,15- dioxo- 9- hydroxy- 2,3,4,5- tetranorprostan- 1,20- dioic acidIBA 01/2021 - 12/2017
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 02/2007
2	OrexinsIBA 01/2021 - 01/2018
2	Pentylenetetrazole (Metrazol)IBA 11/2018 - 03/2014
2	Interleukin-13IBA 03/2013 - 11/2012
2	Insulin (Novolin)FDA Link 04/2011 - 03/2010
2	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2011 - 06/2006
2	Prostaglandins EIBA 03/2009 - 02/2007
2	4- benzhydryloxy- 1- (3- (1H- tetrazol- 5- yl- )- propyl)piperidineIBA 06/2006 - 04/2006
1	MucinsIBA 11/2021
1	N- (4- (4- (morpholine- 4- carbonyl)piperidine- 1- yl)phenyl)- 2- phenoxypyrimidine- 5- carboxamideIBA 11/2021
1	suvorexantIBA 01/2021
1	Hypnotics and Sedatives (Sedatives)IBA 01/2021
1	AntioxidantsIBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	crocinIBA 01/2021
1	Orexin Receptor AntagonistsIBA 01/2021
1	Volatile Oils (Essential Oils)IBA 01/2020
1	Opioid Analgesics (Opioids)IBA 01/2020
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2020
1	CholesterolIBA 01/2019
1	Fatty Acid-Binding ProteinsIBA 01/2019
1	AdiponectinIBA 01/2019
1	Triglycerides (Triacylglycerol)IBA 01/2019
1	15-deoxyprostaglandin J2IBA 01/2019
1	Messenger RNA (mRNA)IBA 01/2018
1	Interleukin-1 (Interleukin 1)IBA 01/2018
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 01/2017
1	ColforsinIBA 01/2017
1	1-pentyl-3-(1-naphthoyl)indoleIBA 01/2017
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 01/2017
1	AM 251 (AM251)IBA 01/2017
1	CannabinoidsIBA 01/2017
1	indium-bleomycinIBA 01/2016
1	Bleomycin (Blenoxane)FDA LinkGeneric 01/2016
1	ManganeseIBA 10/2015
1	CopperIBA 10/2015
1	Divalent CationsIBA 10/2015
1	IronIBA 10/2015
1	OvalbuminIBA 07/2015
1	bofu-tsusho-sanIBA 06/2014

Therapy/Procedure

3	Therapeutics 01/2018 - 12/2008
2	Kampo Medicine (Kampo) 01/2021 - 06/2014
1	Ligation 01/2020
1	Transplantation 07/2015